ReadCoor is commercializing a new generation sequencing platform that enables researchers to perform high throughput RNA-Seq while preserving sample morphology and simultaneously providing cellular location and spatial image data.
This powerful tool is the first and only implementation of “In-situ Sequencing” and will revolutionize the next phase in understanding the transcriptome.
ReadCoor is leading the next generation of “omics” by delivering the first panomic spatial sequencing platform to the global audience of researchers, clinicians, pharma and diagnostics companies, and ultimately patients. It is accomplishing this with a fundamental new technology called FISSEQ which simultaneously enables integration of high throughput sequencing, morphometric analysis, cellular location and three dimensional spatial imaging. This uniquely powerful tool is the first and only implementation of “In-situ Sequencing” and will revolutionize the next phase in understanding the transcriptome, introducing vast new opportunities for important and meaningful clinical insight. ReadCoor will fulfill the mission with a comprehensive set of high quality services, systems and actionable information provided to research and healthcare communities worldwide.
Current transcriptomic tools are cumbersome, inadequate and cannot preserve the rich panomic information contained in cellular structures. ReadCoor combines both next generation sequencing and morphometric information for the first time in a new generation sequencing platform that enables researchers to perform high throughput RNA sequencing without dissociating cells, thus preserving important cellular structures, pinpointing transcripts to individual cells in 3D, and delivering high fidelity spatial image data.
HISTORY & MISSION
ReadCoor is a creation of the Wyss Institute for Biologically Inspired Engineering at Harvard University. The Wyss emphasizes the use of Nature’s design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world.
ReadCoor personifies these aims in the development of Fluorescence In-situ Sequencing – FISSEQ, first published in the journal Science (Feb 2014, Highly multiplexed three-dimensional subcellular transcriptome sequencing in situ). FISSEQ brings together for the first time next generation sequencing and three-dimensional imaging technologies. This powerful combination enables unprecedented insight into the inner working of the “Panome” of genes, in particular the transcriptome, in “Nature’s” spatial context. ReadCoor will be at the forefront of delivering sequencing services and platforms to research institutions throughout the world.
Invented by a team headed by Wyss Core Faculty member and founder of ReadCoor George Church, FISSEQ is currently in use by a Wyss-led, IARPA-funded consortium mapping neuronal connectomics to discover the brain’s learning patterns and synaptic design, toward the goal of advancing neural-derived machine learning algorithms.
FISSEQ is a spatial gene sequencing technology that reads and visualizes the three-dimensional coordinates of RNA and mRNAs – the working copies of genes – of intact tissue, a capability that stands to revolutionize the way growth and development of cells and tissues is understood. ReadCoor has the exclusive rights to bring FISSEQ technology to market according to a worldwide licensing agreement inked with Harvard’s Office of Technology Development.
“FISSEQ reveals the dimensional context of the molecular protein interactions underpinning both healthy tissue development and the changes that bring about disease,” said ReadCoor’s CEO Shawn Marcell. “Several Wyss partners in both academia and industry are already advancing their research using FISSEQ, and with the launch of ReadCoor we are excited to expand the offering of FISSEQ toward an even broader range of applications.”